Active ingredient (common name):	Sildenafil Citrate
Indication:	Erectiestoornis
Manufacturer:	Pfizer Inc.
Packaging:	4 tabletten in 1 strip
Power:	100mg

Viagra is the brand name for sildenafil citrate, a drug that was originally studied for use in patients with high blood pressure or heart disease. It works by blocking the action of an enzyme called PDE5. The role of this enzyme is to break down another enzyme called cgmP, which relaxes the smooth muscle of the corpus cavernosa (a mass of erectile tissue in the penis), which allows them to become filled with blood and therefore create an erection.

What Is Viagra?

Viagra from india, the ‘little blue pill‘ that is used by millions of men worldwide for erectile dysfunction, was actually discovered by accident.

Viagra is a medication used to treat erectile dysfunction (ED) in men. The active ingredient in Viagra is sildenafil citrate, and it belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. Erectile dysfunction is a condition where a man has difficulty achieving or maintaining an erection during sexual activity.

The mechanism of action of Viagra involves the inhibition of the enzyme phosphodiesterase type 5. This enzyme normally breaks down cyclic guanosine monophosphate (cGMP), a substance that plays a role in smooth muscle relaxation. By inhibiting PDE5, Viagra increases the levels of cGMP, promoting the relaxation of smooth muscles in the blood vessels of the penis. This, in turn, allows for increased blood flow to the penis, facilitating the achievement and maintenance of an erection.

Viagra, developed by the pharmaceutical company Pfizer, was initially developed in the early 1990s as a medication to treat hypertension (high blood pressure) and angina pectoris (a form of chest pain). The active ingredient in Viagra is sildenafil citrate. During clinical trials for these cardiovascular conditions, it was observed that sildenafil had a noticeable effect on enhancing erections in male participants.

Recognizing the potential for a new treatment for erectile dysfunction (ED), Pfizer shifted the focus of its development, and in 1998, Viagra was approved by the U.S. Food and Drug Administration (FDA) for the treatment of ED. Since then, it has become one of the most widely prescribed medications for erectile dysfunction globally.

Viagra works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which plays a role in regulating blood flow. By blocking PDE5, Viagra increases the levels of cyclic guanosine monophosphate (cGMP), leading to the relaxation of smooth muscles in the blood vessels of the penis and an increased flow of blood to the area. This physiological process aids in achieving and sustaining an erection when sexually stimulated.

How does sildenafil treat erectile dysfunction?

Sildenafil is a medication used to treat erectile dysfunction (ED), a condition where a man has difficulty achieving or maintaining an erection. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

Here’s how it works:

Release of Nitric Oxide (NO): Sexual stimulation leads to the release of nitric oxide in the erectile tissue of the penis during arousal. Nitric oxide then activates an enzyme called guanylate cyclase.
Increased cGMP Production: Guanylate cyclase converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). cGMP is a signaling molecule that plays a crucial role in relaxing smooth muscles, including those in the penile arteries.
Smooth Muscle Relaxation: As the levels of cGMP increase, the smooth muscles in the penile arteries relax. This relaxation allows blood to flow into the penis more freely, leading to an erection.
Improved Blood Flow: The relaxation of smooth muscles and the increased levels of cGMP result in improved blood flow to the penile tissues, leading to engorgement and erection.
Inhibition of PDE5: Normally, the effects of cGMP are short-lived because an enzyme called phosphodiesterase type 5 (PDE5) breaks it down. Sildenafil inhibits PDE5, preventing it from breaking down cGMP too quickly. This inhibition helps to prolong the vasodilation and maintain an erection for a longer duration.

How does Viagra work?

Viagra doesn’t cause a man be sexually stimulated. Viagra is just effective if you are sexually aroused. To comprehend how it functions you want to understand the mechanics of how a man gets an erection. When you get sexually stimulated, the nervous system in the erectile tissue of your penis discharges nitric oxide (NO).

The nitric oxide stimulates a protein that produces something many refer to as a messenger cyclic guanosine monophosphate (cGMP). The cGMP loosens up the smooth muscle cells. One result of this is that the conduits in your penis widen and the blood can flow into your penis all the more without any problem. Another result is that the erectile tissue itself loads up with blood. Both of these cycle bring about an erection. Viagra works by keeping up with the degree of cGMP in the smooth muscle cells.

If you are not turned on, your brain will not stimulate the release of any nitric oxide and you will not produce any cGMP.

Is Viagra effective?

Yes, Viagra (sildenafil) is generally effective in treating erectile dysfunction (ED) in men. Clinical studies have demonstrated its efficacy in improving the ability to achieve and maintain an erection sufficient for satisfactory sexual activity.

If I have a heart condition can I take it?

If you have a heart condition you really should examine this with the specialist before to taking Viagra. Viagra may not be fitting a direct result of the risk of collaborating with the nitrates.

What dose Viagra is right for me?

The doctor needs to decide which dosage of Viagra is most appropriate.

Standard Dosing: The starting dose for Viagra is 50 mg taken about 1 hour before sexual activity. However, the dose can be adjusted based on individual response and tolerability.
Individual Response: Your healthcare provider may consider adjusting the dose based on how well you respond to the initial dose. Some individuals may find the 50 mg dose effective, while others may need a higher or lower dose.
Maximum Dosage: The maximum recommended dose is 100 mg per day. It’s important not to exceed this limit without consulting your healthcare provider, as higher doses may increase the risk of side effects.
Special Considerations: Individuals with certain medical conditions or those taking specific medications may require special consideration when determining the appropriate dose. For example, individuals with liver or kidney problems may need lower doses.

Viagra are the side-effects?

Viagra can have potential side effects. It’s important to note that not everyone will experience these side effects, and they can vary in intensity. Common side effects of Viagra:

Headache: This is one of the most commonly reported side effects.
Facial flushing: Some people may experience redness or warmth in the face.
Indigestion: Upset stomach or digestive issues can occur.
Nasal congestion: Stuffy or runny nose may occur.
Dizziness: Some individuals may feel lightheaded or dizzy.
Blurred vision: Vision changes, including blurred vision, have been reported in some cases.

Viagra are there doses?

Yes, Viagra (sildenafil) is available in different doses to accommodate individual needs. The typical doses of Viagra are 25 mg, 50 mg, and 100 mg. The recommended starting dose is often 50 mg, but your healthcare provider may adjust the dosage based on factors such as your age, overall health, and the severity of your erectile dysfunction.

FAQs

What is Viagra?
- Viagra is a brand name for the drug sildenafil, which belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. It is primarily used to treat erectile dysfunction (ED), a condition where a man has difficulty achieving or maintaining an erection.
How does Viagra work?
- Viagra works by increasing blood flow to the penis, helping men to achieve and sustain an erection when sexually aroused. It inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the breakdown of cGMP, a substance that relaxes smooth muscle cells in the penis.
What are the available doses of Viagra?
- Viagra comes in various doses, including 25 mg, 50 mg, and 100 mg tablets. The appropriate dose for an individual depends on factors such as overall health, the severity of ED, and other medications they may be taking.
How should I take Viagra?
- Viagra is typically taken about 30 minutes to an hour before sexual activity. It can be taken with or without food, but it may take longer to work if taken with a high-fat meal. It’s important not to take more than one dose per day.
Are there any side effects of Viagra?
- Common side effects may include headaches, facial flushing, upset stomach, and nasal congestion. Serious side effects are rare but can include sudden vision or hearing loss, chest pain, and priapism (prolonged and painful erection). If you experience any severe side effects, seek medical attention promptly.
Can I take Viagra with other medications?
- It’s crucial to inform your healthcare provider about all the medications you are currently taking, as some drugs may interact with Viagra. In particular, nitrates (commonly used for chest pain) should not be taken with Viagra, as the combination can lead to a dangerous drop in blood pressure.
Is Viagra only for men with erectile dysfunction?
- Yes, Viagra is primarily prescribed for men with erectile dysfunction. It is not intended for use by women or individuals without erectile issues.